Santa Fe Vacations from $1,001
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Your Santa Fe Vacation
Our vacation packages to Santa Fe let you customize your own adventure. Tailor your getaway to suit your interests and needs and make the most of your time in this interesting city. Want to explore your surroundings? Alto de Piedra Waterfall, Town Square and Cerro Tute are some of the most popular places to visit during your trip to Santa Fe. Stop daydreaming and start traveling. Browse the wide range of options on Expedia today and finally put your Santa Fe vacation plans into motion!
The Latest Santa Fe vacation packages
Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo
Casco Viejo
$1,113
per person
Oct 8 - Oct 14
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,000 reviews)
El hotel está perfectamente ubicado. El edificio está impecable.
Reviewed on Aug 7, 2026
Casa Mallet by Wynwood House
Casco Viejo
$1,533
per person
Sep 23 - Sep 28
found 14 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.8/10 Exceptional! (27 reviews)
Well appointed, friendly staff on site and excellent location. Noise from the outside does get in but it didnt bother us too much. Would definitely stay again!
Reviewed on Jul 28, 2026
Stay near popular Santa Fe attractions
Alto de Piedra Waterfall
7.6/10 (7 reviews)
Commune with nature and explore the great outdoors at Alto de Piedra Waterfall during your travels in Santa Fe. While you're in the area, wander around the natural setting.
Quebrada Las Trancas Spa
8.0/10 (2 reviews)
Commune with nature and explore the great outdoors at Quebrada Las Trancas Spa during your travels in Santa Fe. While you're in the area, wander around the natural setting.
Town Square
7.6/10 (11 reviews)
You can find out about the history of Santa Fe with a stop at Town Square. Amble around the area's riverfront or visit its churches.
Orchid House
5.6/10 (5 reviews)
Explore the great outdoors at Orchid House, a lovely green space in Santa Fe. Stroll along the riverfront or visit the churches while you're in the area.
Catholic Church of Santa Fe
8.4/10 (5 reviews)
After visiting Catholic Church of Santa Fe, make a plan to see the other sights and activities in Santa Fe. Stroll along the riverfront or visit the churches while you're in the area.
Mercado
8.0/10 (1 review)
Find out about the history of Santa Fe when you spend time at Mercado. Stroll along the riverfront or visit the churches while you're in the area.
Santa Fe Hotel Deals
Hotel Anachoreo
Calle Chinita Santa Fe Veraguas Province
Fully refundableReserve now, pay when you stay
$85 nightly
$93 total
Aug 9 - Aug 10
Total with taxes and fees
9.6/10 Exceptional! (45 reviews)
"Great property location and beautiful views, room and bath areas great. Breakfast was solid. Hot water was very inconsistent, usually cold. WiFi great"
Reviewed on Jul 24, 2026
Cabana Vergara Santa Fe
Provincia de Veraguas, Panama Panama
$160 nightly
$160 total
Aug 9 - Aug 10
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santa Fe Vacation Packages
Santa Fe Essential Information
Language | Spanish |
|---|---|
Currency | Panamanian balboas |
Local Welcome | ¡Hola! |
Local Goodbye | Adiós |
Population | 970 |
Max Temp Winter | 90ºF |
Max Temp Summer | 85ºF |
Top Sights | Alto de Piedra Waterfall, Cascada de Bermejo and Town Square |
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Frequently asked questions
How much does a Santa Fe vacation package cost?
You'll find cheap prices from $1,001 on Expedia for your Santa Fe break. However, factors like the season, length of stay and your choice of hotel will determine how much your vacation to Santa Fe costs.
What are the cheapest months to go to Santa Fe?
If you're looking to score a cheap Santa Fe vacation package, consider traveling in April, July and August. You'll generally find lower prices on airfares and hotels during these quieter months — perfect for a budget-friendly break.
How many days is enough for Santa Fe?
Typically, a handful of days is enough to check out the main attractions during your Santa Fe vacation. But if you'd like to have some time to rest or go on day trips, think about extending your itinerary.
Is it worth booking a vacation package to Santa Fe?
Well known for its nature, hiking and a host of other highlights, you can be certain Santa Fe is a good vacation destination. Some of the top attractions to put on your to-do list? Don't miss Alto de Piedra Waterfall and Town Square during your Santa Fe vacation.
How to find the best Santa Fe package deals?
Start your search for a Santa Fe package deal by entering your preferred travel dates and destination under our "Packages" tab. Then add some filters, like "Property type" and "Amenities," to tailor the results to your exact needs. You can also sort by "Package discount" and browse offers that come with big savings. If you don't find the perfect Santa Fe package deal straight away, just play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Fe getaway off to a flying start.
Is it cheaper to book a Santa Fe vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Santa Fe vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Santa Fe?
Enjoy incredible discounts by reserving your flights early with Expedia. If being spontaneous is more your thing, grab one of our last-minute deals for an impromptu Santa Fe trip.
Does Expedia offer Book Now, Pay Later Santa Fe vacation packages?
Secure your ideal getaway to Santa Fe with Expedia's Book Now, Pay Later vacations. There's no need to scrimp and save or wait for your next paycheck — we've partnered with online lender Affirm to give you more flexibility and choice. Our vacation packages with payment plans let you spread the total cost over 3, 6 or 12 months. With no hidden or late payment fees, it's a breeze to stick to your budget and snap up bargains before they disappear.
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
